Wrap it up! Should we take it?

Enhancing remyelination in disease--can we wrap it up?

Demyelinating disorders of the central nervous system are among the most crippling neurological diseases affecting patients at various stages of life. In the most prominent demyelinating disease, multiple sclerosis, the regeneration of myelin sheaths often fails due to a default of the resident stem/precursor cells (oligodendrocyte precursor cells) to differentiate into mature myelin forming ce...

Erythema nodosum :what should we consider about it?

Dynamic cardiomyoplasty: time to wrap it up?

Fifteen years ago Larry Stevenson, in his memorable lectures, pointed to the great sheet of muscle that is the lat-issimus dorsi, and proposed that this potential power source should be harnessed for the purpose of circulatory assistance, and put to much better use as a cardiac muscle in patients handicapped and dying of heart failure. 1 Salmons and others 2 3 had demonstrated that this fast tw...

Synaptic Plasticity: Astrocytes Wrap It Up

In the brain, astrocytes dynamically interact with neuronal synapses via fine processes. New data show that, in response to synaptic plasticity stimuli, astrocyte processes rapidly move towards and enwrap active synapses, aiding in the stabilization and maintenance of active connections.

“Take it up a NOTCH

Long-term survival of ovarian cancer patients is poor due to lack of early detection and high rates of therapeutic failure and chemoresistance. It is estimated that 15,500 women in the United States will die of ovarian cancer this year, and that nearly 23,000 more will receive a first-time diagnosis, 67% of whom will present with advanced stage disease (stages III and IV). Only 5,200 of those a...